Pregnancy category d etoposide can cause fetal harm when administered to a pregnant woman. Etoposide binding ratio correlates directly with serum albumin in patients with cancer and in normal volunteers. A preparation containing etoposide phosphate can be given by intravenous. Etopophos, innetoposide phosphate european medicines agency. Requirement for etoposide in the initial treatment of. Oct 12, 2017 etoposide binding ratio correlates directly with serum albumin in patients with cancer and in normal volunteers. Advise males to use effective contraception for 4 months, after the last dose of etopophos.
Etoposide oral chemotherapy education page 3 side effects of etoposide the common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the left side of this table. The unbound fraction of etoposide significantly correlated with bilirubin in a population of cancer patients. Our etopophos etoposide phosphate side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking. The combination of irinotecan and etoposide was found to have modest clinical activity, with a 55% response rate by recist criteria fig. Clinically important side effects are in bold, italics. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different dose schedules for treatment of a wide variety of malignancies. Some of these patients had preexisting cardiovascular disease, and these cardiovascular side effects were attributed to the large volumes of ns used as the diluent for administration of the drug.
After surviving cancer, what about late life effects of. Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of what to expect. Myelosuppression, nausea, and vomiting are the most common adverse effects. In 100 people receiving cisplatin, etoposide, more than 20 and up to 100 may have. The predominant macromolecular effect of etoposide appears to be the. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online web or by phone 18003321088. Nov 09, 2018 etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. Options to help manage any side effects that do occur are included on the right side of this table. However, there are at least two case reports of hypersensitivity reactions with an alternative formulation of etoposide, etoposide. Hlh patients, initial treatment with etoposide is essential for improving the prognosis. This article also covers several other topics, such as potential side effects, dosing guidelines, and general safety.
Call your doctor for medical advice about side effects. Etoposide is a podophyllotoxin derivative that inhibits dna topoisomerase ii, with resultant dna strand breaks and. In 100 people receiving cisplatin, etoposide, more than 20 and up to. Etoposide, vp16 is a substrate for the drug transporter pglycoprotein pgp. In summary, cddp treatment causes many severe late stage side effects that are tissue specific and resemble accelerated aging. However, biliary excretion of unchanged drug andor metabolites is an important route of etoposide elimination and the unbound free.
It is used to treat small cell lung cancer and other cancers. Each of the side effects above was reported in 20% or greater of patients treated with etoposide. Etoposide can be administered either as intravenous. If you experience a serious side effect, you or your doctor may send a. The most prominent side effects were myelosuppression and gi toxicity. Etoposide definition of etoposide by the free dictionary. Dna strand breaks by inhibiting the action of topoisomerase ii and producing free radicals. Vepesid etoposide chemotherapy, side effects navigating care. The following adverse reactions were reported from etopophos and associated names clinical studies and. After treatment with etoposide has ended, normal hair growth should return. Side effects of etopophos etoposide phosphate, warnings, uses. Etoposide intravenous route side effects mayo clinic. Call your doctor if you have any unusual problems while taking this medication. For parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible side effect of rapid intravenous injection.
It was first synthesized in 1966 and approved for cancer therapy in 1983 by the u. In other words, high doses may produce more severe side effects. Etoposide oral chemotherapy education page 3 side effects of etoposide the common side. Etoposide derives from podophyllotoxin, a toxin found in the american mayapple. Jan 19, 2015 intriguingly, in resting cells inhibition of atm activity with ku55933 blocks ddr and apoptosis by preventing puma expression and caspase activation, while the same protocol increases the cytotoxic effects of etoposide on proliferating tumor cells korwek et al. You may report side effects to the fda at 1800fda1088.
Interferon can cause many different types of sideeffects including anemia. Possible side effects of cisplatin, etoposide table version date. Carboplatin and etoposide macmillan cancer support. An anonymous network of people affected by cancer which is free to join.
Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate. Etoposide is an inhibitor of the enzyme topoisomerase ii, derived from podophyllum peltatum, the mayapple, a perennial herbaceous plant. Vepesid, vp16 about this drug etoposide is used to treat cancer. In a multidrug regimen, each medication has unique side effects. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main side effects of the oral form. Doctors give trusted answers on uses, effects, side effects, and cautions.
Etoposide is used for small cell lung cancer, testicular cancer etc. Etoposide side effects, dosage, interactions drugs. Doctors give trusted answers on uses, effects, sideeffects, and cautions. A preparation containing etoposide phosphate can be given by intravenous injection or infusion. Etopophos as 100 mg single dose preservativefree vials of lyophilized powder. Specific guidelines for dosage adjustments in hepatic impairment are not provided by the manufacturer. Possible side effects more common nausea and throwing up vomiting. This is not a complete list of side effects and others may occur. This article also covers several other topics, such as potential side effects, dosing guidelines, and general safety precautions to discuss with your healthcare provider before beginning treatment. Data have suggested a significant inverse correlation between serum albumin concentration and free. Warnings and precautions severe bone marrow depression this drug may raise your risk of getting a second cancer, such as leukemia low blood pressure with rapid infusion of the medication. Talk to your care provider or dentist before any scheduled procedures.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Our vepesid etoposide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Your doctor can give you drugs to help control some side effects. Etoposide, sold under the brand name etopophos among others, is a chemotherapy medication used for the treatments of a number of types of cancer. When cancer patients are cured due to cddp therapy, they unfortunately often experience severe long. Some side effects of etoposide may occur that usually do not need medical attention. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. Side effects that you should report to your doctor or health care professional as soon as possible. Read more about the prescription drug etoposide oral. Some of these patients had preexisting cardiovascular disease, and these cardiovascular side effects were. Etoposide can cause fetal harm when administered to a pregnant woman. Consumer information about the medication etoposide oral vepesid, includes side effects, drug interactions, recommended dosages, and storage information. You may get some of the side effects we mention, but you are unlikely to get all of them. In clinical studies, the most commonly reported carboplatin plus etoposide drug side effects are shown here.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Etoposide oral vepesid side effects, medical uses, and. Side effects are often predictable in terms of their onset and duration. Etoposide 20mgml concentrate for solution for infusion etoposide. Important things to remember about the side effects of etoposide. To learn more about this drugs mechanism of action, click etoposide. These side effects may go away during treatment as your body adjusts to the.
Jan 26, 2020 some side effects of etoposide may occur that usually do not need medical attention. Effect of etoposide on the pharmacokinetics of other drugs. Apr 10, 2018 talk to your care provider or dentist before any scheduled procedures. Etoposide can be administered either as intravenous infusion or in oral form. The side effects of etoposide and their severity depend on how much of the drug is given. Instructions on how you can make a pdf version of this page using the print function on your browser. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different. Know etoposide uses, sideeffects, composition, substitutes, drug interactions, precautions, dosage, warnings only on. Other side effects not listed may also occur in some patients. Requirement for etoposide in the initial treatment of epstein. Effect of etoposide phosphate on the pharmacokinetics of other drugs. Etoposide side effects, dosage, interactions drugs everyday health search. Etopophos etoposide injection chemotherapy, side effects.
After surviving cancer, what about late life effects of the cure. Side effects are almost always reversible and will go away after treatment is complete. Molecular mechanisms of etoposide pubmed central pmc. Etoposide fda prescribing information, side effects and uses. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these. Infection, especially when white blood cell count is low.
Carboplatin and etoposide chemotherapy is used to treat small cell cancers, including small cell lung cancer, small cell bladder cancer and some types of gynaecological cancer. However, biliary excretion of unchanged drug andor metabolites is an important route of etoposide elimination and the unbound free fraction of etoposide significantly correlates with increased bilirubin in cancer patients. These symptoms may happen within one to six hours after getting this drug. However, for children, considering the side effects of etoposide, including myelosuppression, teratogenesis, etc. Etoposide toposar, vepesid, vp16 upmc hillman cancer. If you notice any other effects, check with your healthcare professional. Find patient medical information for etoposide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. If these drugs are used together, closely monitor for. Find information about common, infrequent and rare side effects of etoposide oral. Always tell your doctor, nurse or pharmacist about any side effects you have. Side effects of etopophos etoposide phosphate, warnings. Toposar should be given only by slow intravenous infusion usually over a 30 to 60minute period since hypotension has been reported as a possible side effect of rapid intravenous. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
Nov 16, 2016 cisplatin cddp is a frequently employed chemotherapeutic drug both in curative and palliative settings. Most people do not experience all of the side effects listed. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main sideeffects of the oral form. Interferon can cause many different types of side effects including anemia, low white blood cell counts, low platelet counts, decreased appetite, tiredness, fatigue and depression. Etoposide phosphate side effects, dosage, interactions. Tell a friend about us, add a link to this page, or visit the webmasters page for free. It may be used before you get a stem cell transplant. However, for children, considering the side effects of etoposide, including. If you are also having treatment with other cancer drugs, you may have some side effects that we have not listed here. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etoposide may be given orally or by slow intravenous infusion, the oral dose being double the intravenous dose.
Advise females of potential risk to the fetus and to use effective contraception during treatment with etopophos monthsand for 6 after final dose. Oral etoposide 50 mgm 2 daily for 21 days every 28 days is a reasonable choice, especially for patients with slowgrowing disease who desire an oral agent. Drug name mechanism of action and pharmacokinetics indications and status adverse effects dosing administration. The common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the. Etoposide uses, side effects, substitutes, composition. Etoposide capsules etoposide dose, indications, adverse. A phase ii study of irinotecan and etoposide as treatment. Toposar etoposide dose, indications, adverse effects. For parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible. Etoposide side effects, dosage, interactions drugs everyday. Data have suggested a significant inverse correlation between serum albumin concentration and free fraction of etoposide.